2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Blake Corum | Michigan | SO | RB | 7 | 5 | 4 | 4 | 2 | 1 | 0 | 0 |
| 1 | TreVeyon Henderson | Ohio State | FR | RB | 9 | 8 | 6 | 5 | 2 | 1 | 0 | 0 |
| 1 | Broc Thompson | Purdue | JR | WR | 8 | 3 | 2 | 2 | 2 | 2 | 0 | 0 |
| 4 | Braelon Allen | Wisconsin | FR | RB | 8 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 4 | Andrel Anthony | Michigan | FR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 4 | Chris Autman-Bell | Minnesota | SR | WR | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Daylen Baldwin | Michigan | SR | WR | 9 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 4 | David Bell | Purdue | JR | WR | 7 | 9 | 6 | 3 | 1 | 0 | 0 | 0 |
| 4 | Ronnie Bell | Michigan | SR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Ji'Ayir Brown | Penn State | SR | S | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Stephen Carr | Indiana | SR | RB | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Aron Cruickshank | Rutgers | JR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Jahan Dotson | Penn State | SR | WR | 6 | 6 | 4 | 1 | 1 | 1 | 1 | 0 |
| 4 | Payne Durham | Purdue | JR | TE | 7 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 4 | Donovan Edwards | Michigan | FR | RB | 8 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | Emeka Egbuka | Ohio State | FR | WR | 7 | 8 | 2 | 1 | 1 | 0 | 0 | 0 |
| 4 | Tyler Goodson | Iowa | JR | RB | 7 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Isaac Guerendo | Wisconsin | JR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Cal Haladay | Mich St | FR | LB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | A.J. Henning | Michigan | SO | WR | 9 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Evan Hull | N'western | SO | RB | 6 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 4 | Cornelius Johnson | Michigan | JR | WR | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Charlie Jones | Iowa | SR | WR | 8 | 7 | 3 | 1 | 1 | 1 | 0 | 0 |
| 4 | Ivory Kelly-Martin | Iowa | SR | RB | 7 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Cameron Martinez | Ohio State | FR | SAF | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Chez Mellusi | Wisconsin | JR | RB | 7 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Chris Olave | Ohio State | SR | WR | 8 | 8 | 3 | 1 | 1 | 0 | 0 | 0 |
| 4 | Jayden Reed | Mich St | JR | WR | 8 | 6 | 3 | 1 | 1 | 1 | 1 | 0 |
| 4 | Samori Toure | Nebraska | SR | WR | 8 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | Miyan Williams | Ohio State | FR | RB | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Garrett Wilson | Ohio State | JR | WR | 8 | 3 | 3 | 3 | 1 | 1 | 0 | 0 |
| 4 | Roman Wilson | Michigan | SO | WR | 9 | 5 | 3 | 1 | 1 | 1 | 0 | 0 |
| 4 | Craig Young | Ohio State | SO | SAF | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |