2021 Big Ten Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Michigan State | 3 | 3 | 95 | 1 | 1.00 |
| 2 | Maryland | 4 | 1 | 45 | 0 | 0.25 |
| 3 | Nebraska | 5 | 4 | 34 | 0 | 0.80 |
| 4 | Minnesota | 2 | 1 | 23 | 0 | 0.50 |
| 5 | Ohio State | 4 | 1 | 20 | 0 | 0.25 |
| 6 | Indiana | 5 | 4 | 19 | 0 | 0.80 |
| 7 | Penn State | 5 | 4 | 15 | 1 | 0.80 |
| 8 | Purdue | 4 | 5 | 9 | 0 | 1.25 |
| 9 | Michigan | 4 | 3 | 6 | 0 | 0.75 |
| 10 | Wisconsin | 3 | 1 | 2 | 0 | 0.33 |
| 11 | Iowa | 2 | 3 | 1 | 0 | 1.50 |
| 12 | Illinois | 1 | 1 | 0 | 0 | 1.00 |
| 12 | Rutgers | 4 | 1 | 0 | 0 | 0.25 |