2022 Conference USA Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 11 | 16 | 69 | 85 | 7.73 |
| 2 | UTSA | 12 | 13 | 65 | 78 | 6.50 |
| 3 | UAB | 11 | 7 | 57 | 64 | 5.82 |
| 4 | Western Kentucky | 11 | 17 | 37 | 54 | 4.91 |
| 5 | Florida Atlantic | 10 | 11 | 42 | 53 | 5.30 |
| 5 | North Texas | 13 | 8 | 45 | 53 | 4.08 |
| 7 | Louisiana Tech | 9 | 9 | 34 | 43 | 4.78 |
| 8 | Rice | 11 | 6 | 32 | 38 | 3.45 |
| 8 | UTEP | 11 | 5 | 33 | 38 | 3.45 |
| 10 | Florida International | 11 | 7 | 30 | 37 | 3.36 |
| 11 | Charlotte | 9 | 7 | 19 | 26 | 2.89 |