2022 Atlantic Coast Conference Leaders Total Defense - Games in December/January Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 1 | 55 | 83 | 53 | 138 | 2.60 | 138.0 |
| 2 | Syracuse | 1 | 77 | 138 | 49 | 215 | 4.39 | 215.0 |
| 3 | Duke | 1 | 128 | 198 | 71 | 326 | 4.59 | 326.0 |
| 4 | Wake Forest | 1 | 114 | 215 | 81 | 329 | 4.06 | 329.0 |
| 5 | North Carolina State | 1 | 76 | 266 | 79 | 342 | 4.33 | 342.0 |
| 6 | Pittsburgh | 1 | 128 | 325 | 61 | 453 | 7.43 | 453.0 |
| 7 | Florida State | 1 | 253 | 243 | 84 | 496 | 5.90 | 496.0 |
| 8 | Clemson | 2 | 237 | 524 | 145 | 761 | 5.25 | 380.5 |
| 9 | North Carolina | 2 | 277 | 522 | 118 | 799 | 6.77 | 399.5 |