2022 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina State | 10 | 15 | 34 | 49 | 4.90 |
| 2 | Louisville | 9 | 12 | 24 | 36 | 4.00 |
| 3 | Pittsburgh | 11 | 11 | 56 | 67 | 6.09 |
| 4 | Clemson | 11 | 9 | 49 | 58 | 5.27 |
| 4 | Duke | 10 | 9 | 45 | 54 | 5.40 |
| 4 | Miami (Florida) | 9 | 9 | 34 | 43 | 4.78 |
| 7 | Florida State | 11 | 8 | 31 | 39 | 3.55 |
| 7 | Syracuse | 10 | 8 | 25 | 33 | 3.30 |
| 9 | North Carolina | 10 | 7 | 39 | 46 | 4.60 |
| 9 | Georgia Tech | 10 | 7 | 31 | 38 | 3.80 |
| 11 | Virginia | 8 | 5 | 28 | 33 | 4.13 |
| 11 | Boston College | 9 | 5 | 27 | 32 | 3.56 |
| 13 | Virginia Tech | 8 | 4 | 30 | 34 | 4.25 |
| 14 | Wake Forest | 10 | 3 | 47 | 50 | 5.00 |