2016 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 13 | 1755 | 2429 | 875 | 4184 | 4.78 | 321.8 |
| 2 | Virginia Tech | 11 | 1596 | 2122 | 754 | 3718 | 4.93 | 338.0 |
| 3 | Louisville | 10 | 1237 | 2175 | 688 | 3412 | 4.96 | 341.2 |
| 4 | Florida State | 11 | 1222 | 2572 | 747 | 3794 | 5.08 | 344.9 |
| 5 | Miami (Florida) | 9 | 1350 | 2059 | 667 | 3409 | 5.11 | 378.8 |
| 6 | North Carolina State | 9 | 1026 | 2513 | 648 | 3539 | 5.46 | 393.2 |
| 7 | North Carolina | 11 | 2402 | 2037 | 821 | 4439 | 5.41 | 403.5 |
| 8 | Boston College | 9 | 1369 | 2298 | 606 | 3667 | 6.05 | 407.4 |
| 9 | Wake Forest | 9 | 1431 | 2253 | 646 | 3684 | 5.70 | 409.3 |
| 10 | Georgia Tech | 11 | 1987 | 2579 | 756 | 4566 | 6.04 | 415.1 |
| 11 | Virginia | 9 | 1877 | 2186 | 627 | 4063 | 6.48 | 451.4 |
| 12 | Duke | 9 | 1743 | 2373 | 609 | 4116 | 6.76 | 457.3 |
| 13 | Pittsburgh | 11 | 1398 | 3972 | 858 | 5370 | 6.26 | 488.2 |
| 14 | Syracuse | 8 | 2094 | 2243 | 587 | 4337 | 7.39 | 542.1 |