2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 11 | 1170 | 2467 | 775 | 3637 | 4.69 | 330.6 |
| 2 | North Carolina State | 9 | 1144 | 1879 | 607 | 3023 | 4.98 | 335.9 |
| 3 | Syracuse | 9 | 1222 | 1892 | 597 | 3114 | 5.22 | 346.0 |
| 4 | Pittsburgh | 11 | 947 | 3116 | 782 | 4063 | 5.20 | 369.4 |
| 5 | Boston College | 9 | 1739 | 1623 | 587 | 3362 | 5.73 | 373.6 |
| 6 | Florida State | 9 | 1450 | 2061 | 666 | 3511 | 5.27 | 390.1 |
| 7 | Virginia Tech | 10 | 1792 | 2333 | 669 | 4125 | 6.17 | 412.5 |
| 8 | Miami (Florida) | 10 | 1512 | 2639 | 729 | 4151 | 5.69 | 415.1 |
| 9 | Wake Forest | 11 | 2036 | 2548 | 758 | 4584 | 6.05 | 416.7 |
| 10 | Louisville | 10 | 1582 | 2588 | 718 | 4170 | 5.81 | 417.0 |
| 11 | North Carolina | 10 | 1663 | 2681 | 691 | 4344 | 6.29 | 434.4 |
| 12 | Virginia | 9 | 1982 | 2270 | 647 | 4252 | 6.57 | 472.4 |
| 13 | Georgia Tech | 9 | 1653 | 2727 | 645 | 4380 | 6.79 | 486.7 |
| 14 | Duke | 10 | 2111 | 3361 | 734 | 5472 | 7.46 | 547.2 |