2016 Atlantic Coast Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Boston College | 5 | 170 | 604 | 266 | 774 | 2.91 | 154.8 |
| 2 | Clemson | 6 | 696 | 863 | 384 | 1559 | 4.06 | 259.8 |
| 3 | Miami (Florida) | 5 | 456 | 854 | 343 | 1310 | 3.82 | 262.0 |
| 4 | North Carolina State | 5 | 542 | 819 | 327 | 1361 | 4.16 | 272.2 |
| 5 | Duke | 4 | 442 | 824 | 265 | 1266 | 4.78 | 316.5 |
| 6 | Florida State | 5 | 656 | 927 | 316 | 1583 | 5.01 | 316.6 |
| 7 | Georgia Tech | 5 | 749 | 907 | 352 | 1656 | 4.70 | 331.2 |
| 8 | Virginia Tech | 5 | 646 | 1050 | 331 | 1696 | 5.12 | 339.2 |
| 9 | Wake Forest | 5 | 535 | 1209 | 336 | 1744 | 5.19 | 348.8 |
| 10 | Louisville | 5 | 666 | 1086 | 348 | 1752 | 5.03 | 350.4 |
| 11 | North Carolina | 5 | 1153 | 779 | 370 | 1932 | 5.22 | 386.4 |
| 12 | Pittsburgh | 5 | 579 | 1445 | 357 | 2024 | 5.67 | 404.8 |
| 13 | Syracuse | 4 | 606 | 1070 | 283 | 1676 | 5.92 | 419.0 |
| 14 | Virginia | 4 | 704 | 1224 | 295 | 1928 | 6.54 | 482.0 |