2018 American Athletic Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 2 | 368 | 381 | 144 | 749 | 5.20 | 374.5 |
| 2 | Temple | 3 | 530 | 651 | 235 | 1181 | 5.03 | 393.7 |
| 3 | Tulsa | 2 | 437 | 368 | 146 | 805 | 5.51 | 402.5 |
| 4 | SMU | 2 | 430 | 391 | 129 | 821 | 6.36 | 410.5 |
| 5 | UCF | 2 | 270 | 557 | 145 | 827 | 5.70 | 413.5 |
| 6 | South Florida | 2 | 631 | 351 | 154 | 982 | 6.38 | 491.0 |
| 7 | East Carolina | 2 | 395 | 655 | 152 | 1050 | 6.91 | 525.0 |
| 8 | Tulane | 2 | 305 | 797 | 170 | 1102 | 6.48 | 551.0 |
| 9 | Memphis | 2 | 474 | 701 | 162 | 1175 | 7.25 | 587.5 |
| 10 | Houston | 2 | 249 | 986 | 200 | 1235 | 6.18 | 617.5 |
| 11 | Connecticut | 1 | 341 | 295 | 78 | 636 | 8.15 | 636.0 |