2021 Conference USA Leaders Passing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 8 | 192 | 106 | 55.2 | 1416 | 7.4 | 6 | 9 | 118.09 | 24.0 | 177.0 |
| 2 | UTEP | 8 | 246 | 139 | 56.5 | 1632 | 6.6 | 11 | 6 | 122.11 | 30.8 | 204.0 |
| 3 | Marshall | 8 | 249 | 135 | 54.2 | 1537 | 6.2 | 12 | 7 | 116.35 | 31.1 | 192.1 |
| 3 | Louisiana Tech | 8 | 221 | 130 | 58.8 | 1703 | 7.7 | 12 | 6 | 136.04 | 27.6 | 212.9 |
| 3 | North Texas | 8 | 222 | 128 | 57.7 | 1772 | 8.0 | 12 | 3 | 139.85 | 27.8 | 221.5 |
| 6 | UAB | 8 | 252 | 146 | 57.9 | 1532 | 6.1 | 13 | 7 | 120.46 | 31.5 | 191.5 |
| 7 | Middle Tennessee | 8 | 315 | 187 | 59.4 | 2059 | 6.5 | 16 | 10 | 124.69 | 39.4 | 257.4 |
| 7 | Western Kentucky | 9 | 352 | 216 | 61.4 | 2423 | 6.9 | 16 | 18 | 123.96 | 39.1 | 269.2 |
| 7 | Florida Atlantic | 8 | 316 | 195 | 61.7 | 2421 | 7.7 | 16 | 8 | 137.71 | 39.5 | 302.6 |
| 10 | Old Dominion | 8 | 314 | 195 | 62.1 | 2268 | 7.2 | 17 | 7 | 136.18 | 39.3 | 283.5 |
| 10 | Rice | 8 | 266 | 167 | 62.8 | 2360 | 8.9 | 17 | 11 | 150.12 | 33.3 | 295.0 |
| 12 | Florida International | 8 | 228 | 167 | 73.2 | 1990 | 8.7 | 18 | 2 | 170.87 | 28.5 | 248.8 |
| 12 | UTSA | 9 | 280 | 164 | 58.6 | 2335 | 8.3 | 18 | 10 | 142.70 | 31.1 | 259.4 |
| 14 | Charlotte | 8 | 242 | 167 | 69.0 | 2635 | 10.9 | 23 | 7 | 186.04 | 30.3 | 329.4 |