2021 Conference USA Leaders Passing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 11 | 286 | 166 | 58.0 | 2030 | 7.1 | 10 | 10 | 122.21 | 26.0 | 184.5 |
| 2 | UTEP | 13 | 406 | 223 | 54.9 | 2730 | 6.7 | 16 | 8 | 120.48 | 31.2 | 210.0 |
| 3 | Marshall | 12 | 387 | 209 | 54.0 | 2382 | 6.2 | 17 | 10 | 115.04 | 32.3 | 198.5 |
| 4 | UAB | 11 | 358 | 207 | 57.8 | 2254 | 6.3 | 18 | 9 | 122.27 | 32.5 | 204.9 |
| 5 | Florida Atlantic | 12 | 420 | 247 | 58.8 | 2970 | 7.1 | 19 | 13 | 126.95 | 35.0 | 247.5 |
| 6 | Rice | 10 | 323 | 204 | 63.2 | 2910 | 9.0 | 20 | 13 | 151.22 | 32.3 | 291.0 |
| 7 | Western Kentucky | 13 | 489 | 296 | 60.5 | 3426 | 7.0 | 22 | 21 | 125.64 | 37.6 | 263.5 |
| 8 | Middle Tennessee | 13 | 491 | 287 | 58.5 | 3075 | 6.3 | 23 | 17 | 119.60 | 37.8 | 236.5 |
| 8 | Louisiana Tech | 11 | 377 | 249 | 66.0 | 2963 | 7.9 | 23 | 9 | 147.43 | 34.3 | 269.4 |
| 10 | UTSA | 13 | 399 | 233 | 58.4 | 3279 | 8.2 | 24 | 12 | 141.26 | 30.7 | 252.2 |
| 11 | North Texas | 13 | 382 | 228 | 59.7 | 2990 | 7.8 | 25 | 6 | 143.90 | 29.4 | 230.0 |
| 11 | Old Dominion | 12 | 419 | 262 | 62.5 | 3073 | 7.3 | 25 | 7 | 140.49 | 34.9 | 256.1 |
| 13 | Charlotte | 12 | 324 | 209 | 64.5 | 3130 | 9.7 | 27 | 8 | 168.21 | 27.0 | 260.8 |
| 14 | Florida International | 12 | 376 | 258 | 68.6 | 3154 | 8.4 | 28 | 3 | 162.06 | 31.3 | 262.8 |