2021 Conference USA Leaders Opponent First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Rice | 4 | 43 | 30 | 5 | 78 | 19.5 |
| 1 | Charlotte | 4 | 33 | 47 | 5 | 85 | 21.3 |
| 3 | Marshall | 4 | 42 | 21 | 6 | 69 | 17.3 |
| 4 | UTSA | 4 | 24 | 54 | 7 | 85 | 21.3 |
| 4 | Middle Tennessee | 4 | 37 | 44 | 7 | 88 | 22.0 |
| 4 | Florida International | 4 | 50 | 51 | 7 | 108 | 27.0 |
| 7 | Southern Mississippi | 4 | 29 | 29 | 9 | 67 | 16.8 |
| 7 | Florida Atlantic | 4 | 19 | 44 | 9 | 72 | 18.0 |
| 7 | Louisiana Tech | 4 | 34 | 40 | 9 | 83 | 20.8 |
| 7 | Western Kentucky | 5 | 47 | 60 | 9 | 116 | 23.2 |
| 11 | Old Dominion | 4 | 24 | 54 | 10 | 88 | 22.0 |
| 12 | UTEP | 4 | 24 | 27 | 11 | 62 | 15.5 |
| 13 | UAB | 4 | 22 | 36 | 12 | 70 | 17.5 |
| 14 | North Texas | 4 | 34 | 44 | 15 | 93 | 23.3 |