2021 Conference USA Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 1 | 8 | 13 | 1 | 22 | 22.0 |
| 1 | Florida Atlantic | 1 | 17 | 8 | 1 | 26 | 26.0 |
| 3 | North Texas | 1 | 12 | 8 | 2 | 22 | 22.0 |
| 3 | Louisiana Tech | 2 | 14 | 29 | 2 | 45 | 22.5 |
| 3 | Charlotte | 2 | 29 | 14 | 2 | 45 | 22.5 |
| 3 | UAB | 1 | 11 | 10 | 2 | 23 | 23.0 |
| 3 | Middle Tennessee | 1 | 14 | 8 | 2 | 24 | 24.0 |
| 8 | Old Dominion | 1 | 7 | 10 | 3 | 20 | 20.0 |
| 8 | UTSA | 1 | 8 | 13 | 3 | 24 | 24.0 |
| 8 | Florida International | 1 | 11 | 17 | 3 | 31 | 31.0 |
| 11 | Rice | 2 | 28 | 12 | 4 | 44 | 22.0 |
| 12 | Western Kentucky | 2 | 19 | 36 | 6 | 61 | 30.5 |