2021 Conference USA Leaders Opponent First Downs - Games in November Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Florida International | 4 | 59 | 35 | 1 | 95 | 23.8 |
| 2 | Southern Mississippi | 4 | 38 | 29 | 2 | 69 | 17.3 |
| 3 | North Texas | 4 | 22 | 28 | 3 | 53 | 13.3 |
| 4 | Middle Tennessee | 4 | 18 | 39 | 4 | 61 | 15.3 |
| 5 | Western Kentucky | 4 | 28 | 49 | 5 | 82 | 20.5 |
| 5 | Marshall | 4 | 40 | 41 | 5 | 86 | 21.5 |
| 5 | Charlotte | 4 | 45 | 50 | 5 | 100 | 25.0 |
| 8 | UTSA | 4 | 46 | 23 | 7 | 76 | 19.0 |
| 8 | Old Dominion | 4 | 33 | 43 | 7 | 83 | 20.8 |
| 10 | Louisiana Tech | 4 | 38 | 36 | 8 | 82 | 20.5 |
| 11 | Florida Atlantic | 4 | 25 | 58 | 9 | 92 | 23.0 |
| 12 | UTEP | 4 | 38 | 41 | 11 | 90 | 22.5 |
| 12 | Rice | 4 | 27 | 59 | 11 | 97 | 24.3 |
| 14 | UAB | 4 | 24 | 39 | 12 | 75 | 18.8 |