2021 Conference USA Leaders Opponent First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Florida International | 6 | 80 | 68 | 7 | 155 | 25.8 |
| 2 | Louisiana Tech | 6 | 49 | 64 | 8 | 121 | 20.2 |
| 2 | Charlotte | 6 | 57 | 72 | 8 | 137 | 22.8 |
| 4 | Western Kentucky | 8 | 83 | 95 | 9 | 187 | 23.4 |
| 5 | Southern Mississippi | 6 | 32 | 54 | 10 | 96 | 16.0 |
| 5 | Rice | 6 | 60 | 54 | 10 | 124 | 20.7 |
| 7 | Middle Tennessee | 8 | 74 | 88 | 12 | 174 | 21.8 |
| 8 | Florida Atlantic | 6 | 63 | 66 | 15 | 144 | 24.0 |
| 9 | Marshall | 7 | 91 | 57 | 17 | 165 | 23.6 |
| 10 | North Texas | 7 | 51 | 68 | 18 | 137 | 19.6 |
| 10 | Old Dominion | 7 | 62 | 85 | 18 | 165 | 23.6 |
| 12 | UTSA | 7 | 65 | 91 | 19 | 175 | 25.0 |
| 13 | UTEP | 7 | 53 | 60 | 22 | 135 | 19.3 |
| 14 | UAB | 8 | 52 | 58 | 24 | 134 | 16.8 |