2021 Conference USA Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Marshall | 4 | 33.0 | 130 | 8.25 |
| 2 | Southern Mississippi | 4 | 31.0 | 124 | 7.75 |
| 3 | North Texas | 4 | 27.0 | 106 | 6.75 |
| 4 | UTSA | 4 | 26.0 | 109 | 6.50 |
| 5 | UTEP | 4 | 24.0 | 94 | 6.00 |
| 6 | Charlotte | 4 | 23.0 | 95 | 5.75 |
| 6 | Middle Tennessee | 4 | 23.0 | 92 | 5.75 |
| 8 | Florida International | 4 | 22.0 | 77 | 5.50 |
| 9 | Old Dominion | 4 | 20.0 | 93 | 5.00 |
| 10 | Florida Atlantic | 4 | 17.0 | 64 | 4.25 |
| 11 | Rice | 4 | 16.0 | 71 | 4.00 |
| 11 | Louisiana Tech | 4 | 16.0 | 69 | 4.00 |
| 11 | Western Kentucky | 3 | 16.0 | 67 | 5.33 |
| 14 | UAB | 4 | 14.0 | 67 | 3.50 |