2021 Conference USA Leaders Tackles For Loss - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Marshall | 12 | 87.0 | 353 | 7.25 |
| 2 | UTSA | 12 | 78.0 | 356 | 6.50 |
| 3 | UAB | 11 | 75.0 | 338 | 6.82 |
| 4 | Middle Tennessee | 11 | 74.0 | 301 | 6.73 |
| 5 | UTEP | 12 | 71.0 | 275 | 5.92 |
| 6 | North Texas | 11 | 65.0 | 314 | 5.91 |
| 7 | Western Kentucky | 11 | 64.0 | 278 | 5.82 |
| 8 | Old Dominion | 11 | 57.0 | 223 | 5.18 |
| 8 | Florida Atlantic | 10 | 57.0 | 221 | 5.70 |
| 10 | Southern Mississippi | 10 | 56.0 | 221 | 5.60 |
| 11 | Louisiana Tech | 9 | 53.0 | 196 | 5.89 |
| 12 | Rice | 9 | 50.0 | 225 | 5.56 |
| 13 | Florida International | 10 | 48.0 | 140 | 4.80 |
| 14 | Charlotte | 9 | 35.0 | 153 | 3.89 |