2021 Big 12 Conference Leaders Total Defense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 6 | 630 | 1007 | 371 | 1637 | 4.41 | 272.8 |
| 2 | West Virginia | 6 | 766 | 1068 | 372 | 1834 | 4.93 | 305.7 |
| 3 | Kansas | 6 | 1432 | 1171 | 382 | 2603 | 6.81 | 433.8 |
| 4 | Texas | 6 | 1014 | 1247 | 397 | 2261 | 5.70 | 376.8 |
| 5 | Oklahoma State | 7 | 815 | 1327 | 449 | 2142 | 4.77 | 306.0 |
| 6 | TCU | 7 | 1348 | 1499 | 437 | 2847 | 6.51 | 406.7 |
| 7 | Texas Tech | 6 | 828 | 1539 | 416 | 2367 | 5.69 | 394.5 |
| 8 | Kansas State | 7 | 873 | 1616 | 475 | 2489 | 5.24 | 355.6 |
| 9 | Baylor | 7 | 842 | 1724 | 438 | 2566 | 5.86 | 366.6 |
| 10 | Oklahoma | 7 | 655 | 1812 | 486 | 2467 | 5.08 | 352.4 |