2021 Big 12 Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Texas | 3 | 553 | 548 | 191 | 1101 | 5.76 | 367.0 |
| 2 | Iowa State | 4 | 280 | 617 | 243 | 897 | 3.69 | 224.3 |
| 3 | TCU | 3 | 544 | 630 | 175 | 1174 | 6.71 | 391.3 |
| 4 | Kansas | 3 | 659 | 671 | 205 | 1330 | 6.49 | 443.3 |
| 5 | West Virginia | 4 | 554 | 724 | 269 | 1278 | 4.75 | 319.5 |
| 6 | Baylor | 4 | 445 | 802 | 272 | 1247 | 4.58 | 311.8 |
| 7 | Kansas State | 4 | 334 | 814 | 232 | 1148 | 4.95 | 287.0 |
| 8 | Texas Tech | 4 | 217 | 998 | 292 | 1215 | 4.16 | 303.8 |
| 9 | Oklahoma | 4 | 441 | 1014 | 276 | 1455 | 5.27 | 363.8 |
| 10 | Oklahoma State | 4 | 328 | 1209 | 308 | 1537 | 4.99 | 384.3 |