2021 Big 12 Conference Leaders Total Defense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma | 2 | 437 | 331 | 134 | 768 | 5.73 | 384.0 |
| 2 | Oklahoma State | 2 | 129 | 487 | 127 | 616 | 4.85 | 308.0 |
| 3 | Baylor | 2 | 313 | 650 | 159 | 963 | 6.06 | 481.5 |
| 4 | Kansas State | 5 | 861 | 1198 | 348 | 2059 | 5.92 | 411.8 |
| 5 | Iowa State | 6 | 851 | 1234 | 381 | 2085 | 5.47 | 347.5 |
| 6 | West Virginia | 7 | 985 | 1637 | 458 | 2622 | 5.72 | 374.6 |
| 7 | Texas | 7 | 1674 | 1639 | 537 | 3313 | 6.17 | 473.3 |
| 8 | Texas Tech | 6 | 1241 | 1675 | 417 | 2916 | 6.99 | 486.0 |
| 9 | TCU | 7 | 1953 | 1679 | 478 | 3632 | 7.60 | 518.9 |
| 10 | Kansas | 10 | 2669 | 2329 | 665 | 4998 | 7.52 | 499.8 |