2021 Big 12 Conference Leaders Opponent Penalties - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Kansas State | 4 | 25 | 196 | 6.3 | 49.0 |
| 2 | Texas Tech | 4 | 24 | 195 | 6.0 | 48.8 |
| 3 | Kansas | 3 | 18 | 145 | 6.0 | 48.3 |
| 3 | TCU | 3 | 17 | 145 | 5.7 | 48.3 |
| 5 | Iowa State | 4 | 21 | 185 | 5.3 | 46.3 |
| 6 | Oklahoma | 4 | 23 | 183 | 5.8 | 45.8 |
| 6 | Oklahoma State | 4 | 21 | 183 | 5.3 | 45.8 |
| 8 | Texas | 3 | 15 | 105 | 5.0 | 35.0 |
| 9 | West Virginia | 4 | 17 | 136 | 4.3 | 34.0 |
| 10 | Baylor | 4 | 16 | 122 | 4.0 | 30.5 |