2021 Big 12 Conference Leaders Opponent Penalties - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma | 12 | 78 | 640 | 6.5 | 53.3 |
| 2 | Oklahoma State | 13 | 84 | 670 | 6.5 | 51.5 |
| 3 | Texas Tech | 12 | 69 | 594 | 5.8 | 49.5 |
| 3 | Iowa State | 12 | 63 | 594 | 5.3 | 49.5 |
| 5 | Kansas | 11 | 58 | 519 | 5.3 | 47.2 |
| 6 | Kansas State | 12 | 67 | 556 | 5.6 | 46.3 |
| 7 | Baylor | 13 | 68 | 584 | 5.2 | 44.9 |
| 8 | TCU | 11 | 47 | 432 | 4.3 | 39.3 |
| 9 | West Virginia | 12 | 54 | 445 | 4.5 | 37.1 |
| 10 | Texas | 12 | 53 | 442 | 4.4 | 36.8 |