2021 Big 12 Conference Leaders Opponent Penalties - Games Lost Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 2 | 19 | 161 | 9.5 | 80.5 |
| 2 | Iowa State | 6 | 33 | 357 | 5.5 | 59.5 |
| 3 | Texas Tech | 6 | 38 | 346 | 6.3 | 57.7 |
| 4 | Oklahoma | 2 | 13 | 115 | 6.5 | 57.5 |
| 5 | Kansas State | 5 | 27 | 238 | 5.4 | 47.6 |
| 6 | Oklahoma State | 2 | 11 | 89 | 5.5 | 44.5 |
| 7 | Kansas | 10 | 48 | 422 | 4.8 | 42.2 |
| 8 | TCU | 7 | 28 | 268 | 4.0 | 38.3 |
| 9 | West Virginia | 7 | 28 | 245 | 4.0 | 35.0 |
| 10 | Texas | 7 | 27 | 224 | 3.9 | 32.0 |