2021 Big 12 Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 5 | 12 | 167 | 1 | 2.40 |
| 2 | Texas | 5 | 5 | 49 | 0 | 1.00 |
| 3 | Oklahoma | 3 | 4 | 44 | 0 | 1.33 |
| 4 | Texas Tech | 4 | 4 | 13 | 1 | 1.00 |
| 5 | Oklahoma State | 4 | 1 | 11 | 0 | 0.25 |
| 6 | Iowa State | 5 | 2 | 2 | 0 | 0.40 |
| 7 | TCU | 3 | 2 | 0 | 0 | 0.67 |
| 7 | West Virginia | 3 | 2 | 0 | 0 | 0.67 |
| 7 | Kansas State | 3 | 1 | 0 | 0 | 0.33 |
| 7 | Kansas | 3 | 1 | 0 | 0 | 0.33 |