2021 Big 12 Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 6 | 85 | 2 | 1.50 |
| 2 | Kansas | 4 | 1 | 65 | 0 | 0.25 |
| 3 | Kansas State | 4 | 4 | 63 | 0 | 1.00 |
| 4 | TCU | 3 | 4 | 52 | 0 | 1.33 |
| 5 | Texas | 4 | 3 | 51 | 1 | 0.75 |
| 6 | Baylor | 4 | 4 | 42 | 1 | 1.00 |
| 7 | Oklahoma | 4 | 3 | 37 | 0 | 0.75 |
| 8 | Iowa State | 4 | 3 | 20 | 0 | 0.75 |
| 9 | Oklahoma State | 4 | 2 | 1 | 0 | 0.50 |
| 10 | West Virginia | 4 | 1 | 0 | 0 | 0.25 |