2021 Big 12 Conference Leaders Interceptions - Games in November Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Kansas | 4 | 4 | 59 | 2 | 1.00 |
| 2 | Oklahoma | 3 | 5 | 32 | 0 | 1.67 |
| 3 | West Virginia | 4 | 4 | 28 | 0 | 1.00 |
| 4 | Iowa State | 4 | 3 | 16 | 0 | 0.75 |
| 5 | Texas Tech | 3 | 2 | 6 | 0 | 0.67 |
| 6 | Baylor | 4 | 3 | 5 | 0 | 0.75 |
| 7 | Kansas State | 4 | 3 | 3 | 0 | 0.75 |
| 8 | TCU | 4 | 3 | 2 | 0 | 0.75 |
| 8 | Oklahoma State | 4 | 1 | 2 | 0 | 0.25 |