2021 Big 12 Conference Leaders Sacks - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 39.0 | 265 | 3.90 |
| 2 | Oklahoma | 10 | 28.0 | 189 | 2.80 |
| 3 | Kansas State | 10 | 24.0 | 137 | 2.40 |
| 4 | West Virginia | 10 | 22.0 | 157 | 2.20 |
| 5 | Baylor | 9 | 21.0 | 139 | 2.33 |
| 6 | Iowa State | 8 | 19.0 | 142 | 2.38 |
| 7 | Texas Tech | 9 | 14.0 | 98 | 1.56 |
| 8 | TCU | 9 | 12.0 | 89 | 1.33 |
| 8 | Texas | 7 | 12.0 | 69 | 1.71 |
| 10 | Kansas | 9 | 11.0 | 76 | 1.22 |