2021 Big 12 Conference Leaders Sacks - Games in August/September Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma | 4 | 14.0 | 83 | 3.50 |
| 2 | Oklahoma State | 4 | 13.0 | 98 | 3.25 |
| 2 | Kansas State | 4 | 13.0 | 78 | 3.25 |
| 2 | West Virginia | 4 | 13.0 | 78 | 3.25 |
| 5 | Iowa State | 4 | 11.0 | 75 | 2.75 |
| 6 | Texas Tech | 4 | 9.0 | 66 | 2.25 |
| 6 | Texas | 4 | 9.0 | 54 | 2.25 |
| 8 | Baylor | 4 | 5.0 | 32 | 1.25 |
| 9 | TCU | 3 | 3.0 | 19 | 1.00 |
| 10 | Kansas | 4 | 2.0 | 8 | 0.50 |