2021 Big 12 Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma State | 3 | 8.0 | 52 | 2.67 |
| 2 | Texas | 2 | 7.0 | 37 | 3.50 |
| 3 | Baylor | 2 | 6.0 | 50 | 3.00 |
| 3 | Texas Tech | 2 | 6.0 | 47 | 3.00 |
| 5 | Oklahoma | 1 | 4.0 | 23 | 4.00 |
| 6 | Kansas State | 1 | 3.0 | 22 | 3.00 |
| 6 | Iowa State | 1 | 3.0 | 12 | 3.00 |
| 8 | Kansas | 1 | 1.0 | 1 | 1.00 |