2021 Atlantic Coast Conference Leaders Rushing Defense - Games at Home Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 6 | 197 | 324 | 1.64 | 3 | 32.83 | 54.00 |
| 2 | Syracuse | 7 | 263 | 613 | 2.33 | 5 | 37.57 | 87.57 |
| 3 | Pittsburgh | 7 | 225 | 652 | 2.90 | 11 | 32.14 | 93.14 |
| 4 | Florida State | 7 | 243 | 784 | 3.23 | 7 | 34.71 | 112.00 |
| 5 | Boston College | 6 | 211 | 776 | 3.68 | 5 | 35.17 | 129.33 |
| 6 | Wake Forest | 6 | 206 | 820 | 3.98 | 3 | 34.33 | 136.67 |
| 7 | Miami (Florida) | 7 | 238 | 1003 | 4.21 | 7 | 34.00 | 143.29 |
| 8 | Louisville | 7 | 241 | 1083 | 4.49 | 11 | 34.43 | 154.71 |
| 9 | North Carolina State | 7 | 237 | 1123 | 4.74 | 5 | 33.86 | 160.43 |
| 10 | North Carolina | 7 | 265 | 1147 | 4.33 | 12 | 37.86 | 163.86 |
| 11 | Virginia Tech | 7 | 283 | 1270 | 4.49 | 10 | 40.43 | 181.43 |
| 12 | Georgia Tech | 6 | 248 | 1140 | 4.60 | 9 | 41.33 | 190.00 |
| 13 | Virginia | 7 | 263 | 1362 | 5.18 | 6 | 37.57 | 194.57 |
| 14 | Duke | 7 | 274 | 1458 | 5.32 | 15 | 39.14 | 208.29 |