2021 Atlantic Coast Conference Leaders Rushing Defense - Games Won Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 10 | 315 | 821 | 2.61 | 7 | 31.50 | 82.10 |
| 2 | Pittsburgh | 11 | 359 | 969 | 2.70 | 10 | 32.64 | 88.09 |
| 3 | Miami (Florida) | 7 | 219 | 759 | 3.47 | 5 | 31.29 | 108.43 |
| 4 | Syracuse | 5 | 189 | 622 | 3.29 | 4 | 37.80 | 124.40 |
| 5 | Boston College | 6 | 198 | 767 | 3.87 | 6 | 33.00 | 127.83 |
| 6 | Virginia Tech | 6 | 204 | 822 | 4.03 | 4 | 34.00 | 137.00 |
| 7 | Georgia Tech | 3 | 140 | 414 | 2.96 | 3 | 46.67 | 138.00 |
| 8 | North Carolina State | 9 | 294 | 1246 | 4.24 | 6 | 32.67 | 138.44 |
| 9 | North Carolina | 6 | 224 | 909 | 4.06 | 10 | 37.33 | 151.50 |
| 10 | Louisville | 6 | 197 | 949 | 4.82 | 6 | 32.83 | 158.17 |
| 11 | Florida State | 5 | 178 | 793 | 4.46 | 6 | 35.60 | 158.60 |
| 12 | Virginia | 6 | 207 | 992 | 4.79 | 8 | 34.50 | 165.33 |
| 13 | Wake Forest | 11 | 419 | 1963 | 4.68 | 12 | 38.09 | 178.45 |
| 14 | Duke | 3 | 120 | 572 | 4.77 | 5 | 40.00 | 190.67 |