2021 Atlantic Coast Conference Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 124 | 281 | 2.27 | 5 | 31.00 | 70.25 |
| 2 | Pittsburgh | 4 | 142 | 282 | 1.99 | 3 | 35.50 | 70.50 |
| 3 | Florida State | 4 | 157 | 438 | 2.79 | 3 | 39.25 | 109.50 |
| 4 | Syracuse | 3 | 96 | 383 | 3.99 | 2 | 32.00 | 127.67 |
| 5 | Virginia Tech | 4 | 156 | 555 | 3.56 | 7 | 39.00 | 138.75 |
| 6 | Miami (Florida) | 4 | 157 | 584 | 3.72 | 5 | 39.25 | 146.00 |
| 7 | North Carolina State | 4 | 145 | 624 | 4.30 | 8 | 36.25 | 156.00 |
| 8 | North Carolina | 4 | 144 | 634 | 4.40 | 5 | 36.00 | 158.50 |
| 9 | Boston College | 4 | 159 | 666 | 4.19 | 4 | 39.75 | 166.50 |
| 10 | Georgia Tech | 4 | 144 | 789 | 5.48 | 9 | 36.00 | 197.25 |
| 11 | Louisville | 4 | 154 | 808 | 5.25 | 10 | 38.50 | 202.00 |
| 12 | Wake Forest | 4 | 153 | 900 | 5.88 | 10 | 38.25 | 225.00 |
| 13 | Virginia | 3 | 123 | 738 | 6.00 | 3 | 41.00 | 246.00 |
| 14 | Duke | 4 | 156 | 1041 | 6.67 | 11 | 39.00 | 260.25 |