2021 Atlantic Coast Conference Leaders Rushing Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 5 | 154 | 356 | 2.31 | 4 | 30.80 | 71.20 |
| 2 | Pittsburgh | 7 | 247 | 597 | 2.42 | 4 | 35.29 | 85.29 |
| 3 | Clemson | 7 | 243 | 928 | 3.82 | 4 | 34.71 | 132.57 |
| 4 | Miami (Florida) | 5 | 191 | 665 | 3.48 | 9 | 38.20 | 133.00 |
| 5 | Virginia Tech | 6 | 198 | 928 | 4.69 | 10 | 33.00 | 154.67 |
| 6 | Louisville | 6 | 226 | 954 | 4.22 | 12 | 37.67 | 159.00 |
| 7 | Georgia Tech | 6 | 243 | 1044 | 4.30 | 10 | 40.50 | 174.00 |
| 8 | Syracuse | 5 | 175 | 900 | 5.14 | 7 | 35.00 | 180.00 |
| 9 | Florida State | 5 | 234 | 951 | 4.06 | 8 | 46.80 | 190.20 |
| 10 | North Carolina | 6 | 239 | 1193 | 4.99 | 11 | 39.83 | 198.83 |
| 11 | Duke | 5 | 194 | 1012 | 5.22 | 11 | 38.80 | 202.40 |
| 12 | Boston College | 6 | 240 | 1267 | 5.28 | 10 | 40.00 | 211.17 |
| 13 | Wake Forest | 8 | 357 | 1918 | 5.37 | 22 | 44.63 | 239.75 |
| 14 | Virginia | 5 | 205 | 1348 | 6.58 | 15 | 41.00 | 269.60 |