2021 Atlantic Coast Conference Leaders First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 3 | 23 | 50 | 10 | 83 | 27.7 |
| 2 | Virginia | 6 | 35 | 111 | 10 | 156 | 26.0 |
| 3 | Miami (Florida) | 5 | 35 | 61 | 19 | 115 | 23.0 |
| 3 | Pittsburgh | 3 | 21 | 43 | 5 | 69 | 23.0 |
| 5 | Duke | 9 | 78 | 90 | 17 | 185 | 20.6 |
| 5 | Louisville | 7 | 64 | 66 | 14 | 144 | 20.6 |
| 7 | North Carolina | 7 | 68 | 66 | 9 | 143 | 20.4 |
| 8 | North Carolina State | 3 | 14 | 42 | 3 | 59 | 19.7 |
| 9 | Georgia Tech | 9 | 75 | 77 | 18 | 170 | 18.9 |
| 10 | Florida State | 7 | 52 | 64 | 15 | 131 | 18.7 |
| 11 | Syracuse | 7 | 66 | 47 | 13 | 126 | 18.0 |
| 12 | Virginia Tech | 7 | 57 | 50 | 11 | 118 | 16.9 |
| 13 | Boston College | 6 | 45 | 40 | 13 | 98 | 16.3 |
| 14 | Clemson | 3 | 11 | 23 | 9 | 43 | 14.3 |