2021 Atlantic Coast Conference Leaders First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 2 | 22 | 32 | 6 | 60 | 30.0 |
| 2 | North Carolina | 2 | 22 | 30 | 4 | 56 | 28.0 |
| 3 | Clemson | 1 | 8 | 15 | 3 | 26 | 26.0 |
| 4 | North Carolina State | 2 | 20 | 25 | 5 | 50 | 25.0 |
| 4 | Miami (Florida) | 1 | 13 | 9 | 3 | 25 | 25.0 |
| 6 | Louisville | 2 | 20 | 25 | 2 | 47 | 23.5 |
| 7 | Duke | 1 | 13 | 9 | 1 | 23 | 23.0 |
| 8 | Virginia Tech | 2 | 22 | 19 | 4 | 45 | 22.5 |
| 8 | Virginia | 2 | 18 | 25 | 2 | 45 | 22.5 |
| 10 | Florida State | 2 | 25 | 16 | 3 | 44 | 22.0 |
| 11 | Syracuse | 2 | 28 | 12 | 3 | 43 | 21.5 |
| 12 | Wake Forest | 2 | 12 | 24 | 6 | 42 | 21.0 |
| 13 | Boston College | 2 | 23 | 12 | 3 | 38 | 19.0 |
| 14 | Georgia Tech | 2 | 21 | 13 | 2 | 36 | 18.0 |