2021 Atlantic Coast Conference Leaders Total Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 8 | 1054 | 3249 | 603 | 4303 | 7.14 | 537.9 |
| 2 | Pittsburgh | 11 | 1711 | 3978 | 860 | 5689 | 6.62 | 517.2 |
| 3 | Wake Forest | 11 | 2013 | 3430 | 833 | 5443 | 6.53 | 494.8 |
| 4 | Louisville | 8 | 1823 | 1951 | 527 | 3774 | 7.16 | 471.8 |
| 5 | Miami (Florida) | 8 | 1234 | 2536 | 591 | 3770 | 6.38 | 471.3 |
| 6 | North Carolina | 9 | 1826 | 2324 | 605 | 4150 | 6.86 | 461.1 |
| 7 | Duke | 10 | 1871 | 2459 | 784 | 4330 | 5.52 | 433.0 |
| 8 | North Carolina State | 10 | 1292 | 2815 | 642 | 4107 | 6.40 | 410.7 |
| 9 | Georgia Tech | 8 | 1633 | 1649 | 536 | 3282 | 6.12 | 410.3 |
| 10 | Florida State | 8 | 1673 | 1606 | 534 | 3279 | 6.14 | 409.9 |
| 11 | Syracuse | 8 | 1848 | 1202 | 518 | 3050 | 5.89 | 381.3 |
| 12 | Clemson | 9 | 1582 | 1835 | 658 | 3417 | 5.19 | 379.7 |
| 13 | Virginia Tech | 11 | 2188 | 1972 | 717 | 4160 | 5.80 | 378.2 |
| 14 | Boston College | 9 | 1677 | 1693 | 599 | 3370 | 5.63 | 374.4 |