2021 Atlantic Coast Conference Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 9 | 981 | 3804 | 700 | 4785 | 6.84 | 531.7 |
| 2 | Wake Forest | 11 | 1742 | 3405 | 902 | 5147 | 5.71 | 467.9 |
| 3 | Pittsburgh | 11 | 1539 | 3478 | 843 | 5017 | 5.95 | 456.1 |
| 4 | Louisville | 10 | 2187 | 2273 | 669 | 4460 | 6.67 | 446.0 |
| 5 | North Carolina | 10 | 2038 | 2363 | 684 | 4401 | 6.43 | 440.1 |
| 6 | Miami (Florida) | 10 | 1035 | 3237 | 733 | 4272 | 5.83 | 427.2 |
| 7 | Duke | 10 | 1663 | 2344 | 790 | 4007 | 5.07 | 400.7 |
| 8 | North Carolina State | 9 | 836 | 2691 | 614 | 3527 | 5.74 | 391.9 |
| 9 | Georgia Tech | 9 | 1470 | 1872 | 586 | 3342 | 5.70 | 371.3 |
| 10 | Virginia Tech | 10 | 1948 | 1735 | 648 | 3683 | 5.68 | 368.3 |
| 11 | Florida State | 9 | 1304 | 1887 | 581 | 3191 | 5.49 | 354.6 |
| 12 | Syracuse | 9 | 1765 | 1322 | 582 | 3087 | 5.30 | 343.0 |
| 13 | Clemson | 11 | 1813 | 1876 | 728 | 3689 | 5.07 | 335.4 |
| 14 | Boston College | 9 | 1364 | 1590 | 602 | 2954 | 4.91 | 328.2 |