2021 Atlantic Coast Conference Leaders Total Offense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina | 2 | 425 | 747 | 143 | 1172 | 8.20 | 586.0 |
| 2 | Duke | 1 | 353 | 228 | 73 | 581 | 7.96 | 581.0 |
| 3 | Pittsburgh | 2 | 298 | 790 | 144 | 1088 | 7.56 | 544.0 |
| 4 | Florida State | 2 | 629 | 399 | 134 | 1028 | 7.67 | 514.0 |
| 5 | Wake Forest | 2 | 344 | 646 | 122 | 990 | 8.11 | 495.0 |
| 6 | Clemson | 1 | 129 | 347 | 100 | 476 | 4.76 | 476.0 |
| 7 | North Carolina State | 2 | 460 | 483 | 133 | 943 | 7.09 | 471.5 |
| 8 | Louisville | 2 | 423 | 504 | 140 | 927 | 6.62 | 463.5 |
| 9 | Virginia | 2 | 298 | 568 | 128 | 866 | 6.77 | 433.0 |
| 10 | Miami (Florida) | 1 | 175 | 200 | 76 | 375 | 4.93 | 375.0 |
| 11 | Boston College | 2 | 429 | 280 | 116 | 709 | 6.11 | 354.5 |
| 12 | Virginia Tech | 2 | 351 | 346 | 138 | 697 | 5.05 | 348.5 |
| 13 | Syracuse | 2 | 511 | 177 | 130 | 688 | 5.29 | 344.0 |
| 14 | Georgia Tech | 2 | 399 | 254 | 141 | 653 | 4.63 | 326.5 |