2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 11 | 92.0 | 448 | 8.36 |
| 2 | Wake Forest | 11 | 80.0 | 285 | 7.27 |
| 3 | Clemson | 9 | 69.0 | 281 | 7.67 |
| 4 | Syracuse | 8 | 64.0 | 254 | 8.00 |
| 5 | Miami (Florida) | 8 | 65.0 | 252 | 8.13 |
| 6 | North Carolina State | 10 | 68.0 | 237 | 6.80 |
| 6 | Louisville | 8 | 55.0 | 237 | 6.88 |
| 8 | Virginia Tech | 11 | 60.0 | 230 | 5.46 |
| 9 | Boston College | 9 | 44.0 | 222 | 4.89 |
| 10 | North Carolina | 9 | 54.0 | 196 | 6.00 |
| 11 | Duke | 10 | 49.0 | 193 | 4.90 |
| 12 | Georgia Tech | 8 | 48.0 | 192 | 6.00 |
| 13 | Florida State | 8 | 53.0 | 170 | 6.63 |
| 14 | Virginia | 8 | 39.0 | 136 | 4.88 |