2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 11 | 92.0 | 423 | 8.36 |
| 2 | Miami (Florida) | 10 | 81.0 | 342 | 8.10 |
| 3 | Wake Forest | 11 | 78.0 | 311 | 7.09 |
| 4 | Clemson | 11 | 72.0 | 309 | 6.55 |
| 5 | Louisville | 10 | 67.0 | 258 | 6.70 |
| 6 | Syracuse | 9 | 58.0 | 255 | 6.44 |
| 7 | North Carolina | 10 | 52.0 | 246 | 5.20 |
| 8 | Florida State | 9 | 61.0 | 213 | 6.78 |
| 9 | North Carolina State | 9 | 62.0 | 212 | 6.89 |
| 10 | Boston College | 9 | 38.0 | 194 | 4.22 |
| 11 | Virginia Tech | 10 | 51.0 | 187 | 5.10 |
| 12 | Duke | 10 | 47.0 | 181 | 4.70 |
| 13 | Georgia Tech | 9 | 45.0 | 164 | 5.00 |
| 14 | Virginia | 9 | 40.0 | 144 | 4.44 |