2021 Atlantic Coast Conference Leaders Tackles For Loss - Games in November Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 40.0 | 182 | 10.00 |
| 2 | Clemson | 4 | 34.0 | 148 | 8.50 |
| 3 | Miami (Florida) | 4 | 36.0 | 134 | 9.00 |
| 4 | North Carolina State | 4 | 33.0 | 132 | 8.25 |
| 5 | Florida State | 4 | 30.0 | 112 | 7.50 |
| 6 | Boston College | 4 | 22.0 | 101 | 5.50 |
| 7 | Wake Forest | 4 | 30.0 | 97 | 7.50 |
| 7 | North Carolina | 4 | 20.0 | 97 | 5.00 |
| 9 | Louisville | 4 | 24.0 | 91 | 6.00 |
| 10 | Virginia Tech | 4 | 22.0 | 88 | 5.50 |
| 11 | Syracuse | 3 | 16.0 | 65 | 5.33 |
| 12 | Virginia | 3 | 12.0 | 57 | 4.00 |
| 13 | Georgia Tech | 4 | 16.0 | 49 | 4.00 |
| 14 | Duke | 4 | 16.0 | 39 | 4.00 |