2021 American Athletic Conference Leaders Total Defense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 12 | 2646 | 2135 | 860 | 4781 | 5.56 | 398.4 |
| 2 | Cincinnati | 14 | 2088 | 2369 | 996 | 4457 | 4.47 | 318.4 |
| 3 | Navy | 12 | 1572 | 2618 | 696 | 4190 | 6.02 | 349.2 |
| 4 | Houston | 14 | 1515 | 2716 | 858 | 4231 | 4.93 | 302.2 |
| 5 | UCF | 13 | 2070 | 2731 | 946 | 4801 | 5.08 | 369.3 |
| 6 | East Carolina | 12 | 1940 | 2782 | 790 | 4722 | 5.98 | 393.5 |
| 7 | Tulsa | 13 | 1857 | 2957 | 885 | 4814 | 5.44 | 370.3 |
| 8 | Memphis | 12 | 2005 | 3011 | 925 | 5016 | 5.42 | 418.0 |
| 9 | South Florida | 12 | 2487 | 3160 | 809 | 5647 | 6.98 | 470.6 |
| 10 | Tulane | 12 | 1901 | 3255 | 888 | 5156 | 5.81 | 429.7 |
| 11 | SMU | 12 | 1651 | 3337 | 842 | 4988 | 5.92 | 415.7 |