2021 American Athletic Conference Leaders Total Defense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | East Carolina | 4 | 695 | 640 | 228 | 1335 | 5.86 | 333.8 |
| 2 | Cincinnati | 4 | 585 | 699 | 286 | 1284 | 4.49 | 321.0 |
| 3 | Houston | 4 | 397 | 780 | 262 | 1177 | 4.49 | 294.3 |
| 4 | Navy | 3 | 392 | 783 | 178 | 1175 | 6.60 | 391.7 |
| 5 | Temple | 4 | 897 | 802 | 292 | 1699 | 5.82 | 424.8 |
| 6 | Tulsa | 4 | 484 | 912 | 276 | 1396 | 5.06 | 349.0 |
| 7 | Tulane | 4 | 421 | 927 | 286 | 1348 | 4.71 | 337.0 |
| 8 | UCF | 4 | 598 | 933 | 309 | 1531 | 4.95 | 382.8 |
| 9 | Memphis | 4 | 748 | 990 | 307 | 1738 | 5.66 | 434.5 |
| 10 | South Florida | 4 | 826 | 1112 | 254 | 1938 | 7.63 | 484.5 |
| 11 | SMU | 4 | 544 | 1180 | 296 | 1724 | 5.82 | 431.0 |