2021 American Athletic Conference Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Memphis | 4 | 805 | 627 | 283 | 1432 | 5.06 | 358.0 |
| 2 | Cincinnati | 5 | 702 | 757 | 346 | 1459 | 4.22 | 291.8 |
| 3 | UCF | 5 | 1032 | 799 | 364 | 1831 | 5.03 | 366.2 |
| 4 | East Carolina | 4 | 575 | 835 | 260 | 1410 | 5.42 | 352.5 |
| 5 | Tulsa | 4 | 710 | 879 | 282 | 1589 | 5.63 | 397.3 |
| 6 | Temple | 4 | 1056 | 902 | 301 | 1958 | 6.50 | 489.5 |
| 7 | SMU | 4 | 561 | 933 | 259 | 1494 | 5.77 | 373.5 |
| 8 | South Florida | 4 | 730 | 960 | 292 | 1690 | 5.79 | 422.5 |
| 9 | Houston | 4 | 257 | 1055 | 269 | 1312 | 4.88 | 328.0 |
| 10 | Navy | 5 | 652 | 1058 | 275 | 1710 | 6.22 | 342.0 |
| 11 | Tulane | 4 | 755 | 1255 | 296 | 2010 | 6.79 | 502.5 |