2021 American Athletic Conference Leaders Total Defense - Games Won Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 2 | 167 | 358 | 138 | 525 | 3.80 | 262.5 |
| 2 | South Florida | 2 | 180 | 431 | 113 | 611 | 5.41 | 305.5 |
| 3 | Temple | 3 | 451 | 532 | 212 | 983 | 4.64 | 327.7 |
| 4 | Navy | 4 | 485 | 549 | 208 | 1034 | 4.97 | 258.5 |
| 5 | East Carolina | 7 | 1220 | 1634 | 469 | 2854 | 6.09 | 407.7 |
| 6 | Memphis | 6 | 811 | 1652 | 449 | 2463 | 5.49 | 410.5 |
| 7 | Tulsa | 7 | 748 | 1753 | 485 | 2501 | 5.16 | 357.3 |
| 8 | UCF | 9 | 954 | 1833 | 631 | 2787 | 4.42 | 309.7 |
| 9 | SMU | 8 | 1154 | 1954 | 535 | 3108 | 5.81 | 388.5 |
| 10 | Cincinnati | 13 | 1787 | 2188 | 921 | 3975 | 4.32 | 305.8 |
| 11 | Houston | 12 | 1160 | 2295 | 761 | 3455 | 4.54 | 287.9 |