2021 American Athletic Conference Leaders First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 5 | 50 | 62 | 11 | 123 | 24.6 |
| 2 | Tulane | 4 | 39 | 45 | 10 | 94 | 23.5 |
| 3 | UCF | 5 | 63 | 61 | 9 | 133 | 26.6 |
| 3 | Memphis | 4 | 34 | 41 | 9 | 84 | 21.0 |
| 5 | Houston | 5 | 34 | 61 | 8 | 103 | 20.6 |
| 5 | Cincinnati | 5 | 41 | 45 | 8 | 94 | 18.8 |
| 7 | South Florida | 4 | 38 | 31 | 7 | 76 | 19.0 |
| 7 | East Carolina | 4 | 22 | 44 | 7 | 73 | 18.3 |
| 7 | Temple | 4 | 27 | 32 | 7 | 66 | 16.5 |
| 10 | SMU | 4 | 49 | 54 | 5 | 108 | 27.0 |
| 11 | Navy | 4 | 42 | 9 | 3 | 54 | 13.5 |