2021 American Athletic Conference Leaders First Downs - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 12 | 117 | 129 | 29 | 275 | 22.9 |
| 2 | Memphis | 11 | 75 | 136 | 27 | 238 | 21.6 |
| 3 | East Carolina | 11 | 97 | 133 | 20 | 250 | 22.7 |
| 4 | Houston | 13 | 93 | 166 | 19 | 278 | 21.4 |
| 5 | UCF | 12 | 105 | 101 | 18 | 224 | 18.7 |
| 6 | South Florida | 11 | 110 | 99 | 17 | 226 | 20.5 |
| 7 | SMU | 11 | 107 | 149 | 16 | 272 | 24.7 |
| 7 | Tulane | 11 | 88 | 98 | 16 | 202 | 18.4 |
| 9 | Cincinnati | 13 | 116 | 130 | 15 | 261 | 20.1 |
| 9 | Navy | 12 | 160 | 27 | 15 | 202 | 16.8 |
| 11 | Temple | 11 | 64 | 79 | 12 | 155 | 14.1 |