2021 American Athletic Conference Leaders First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 7 | 78 | 79 | 21 | 178 | 25.4 |
| 2 | Memphis | 5 | 42 | 70 | 18 | 130 | 26.0 |
| 3 | East Carolina | 6 | 48 | 81 | 13 | 142 | 23.7 |
| 3 | Houston | 9 | 64 | 117 | 13 | 194 | 21.6 |
| 3 | UCF | 6 | 51 | 49 | 13 | 113 | 18.8 |
| 6 | South Florida | 6 | 54 | 53 | 8 | 115 | 19.2 |
| 7 | SMU | 6 | 60 | 65 | 7 | 132 | 22.0 |
| 7 | Cincinnati | 7 | 55 | 70 | 7 | 132 | 18.9 |
| 7 | Tulane | 6 | 51 | 55 | 7 | 113 | 18.8 |
| 10 | Navy | 6 | 76 | 13 | 6 | 95 | 15.8 |
| 10 | Temple | 6 | 34 | 42 | 6 | 82 | 13.7 |