2021 American Athletic Conference Leaders First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Memphis | 6 | 43 | 76 | 19 | 138 | 23.0 |
| 2 | South Florida | 10 | 83 | 93 | 16 | 192 | 19.2 |
| 2 | Tulane | 10 | 79 | 88 | 16 | 183 | 18.3 |
| 4 | Tulsa | 6 | 44 | 58 | 13 | 115 | 19.2 |
| 5 | Navy | 8 | 94 | 20 | 12 | 126 | 15.8 |
| 6 | East Carolina | 5 | 30 | 50 | 10 | 90 | 18.0 |
| 7 | UCF | 4 | 29 | 30 | 9 | 68 | 17.0 |
| 7 | Temple | 9 | 48 | 55 | 9 | 112 | 12.4 |
| 9 | SMU | 4 | 31 | 35 | 6 | 72 | 18.0 |
| 10 | Houston | 2 | 14 | 20 | 3 | 37 | 18.5 |
| 11 | Cincinnati | 1 | 6 | 7 | 0 | 13 | 13.0 |