2021 Mid-American Conference Leaders Rushing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 4 | 147 | 654 | 4.45 | 4 | 36.75 | 163.50 |
| 2 | Toledo | 6 | 259 | 1000 | 3.86 | 7 | 43.17 | 166.67 |
| 3 | Western Michigan | 5 | 190 | 995 | 5.24 | 7 | 38.00 | 199.00 |
| 4 | Buffalo | 8 | 321 | 1615 | 5.03 | 18 | 40.13 | 201.88 |
| 5 | Bowling Green | 8 | 373 | 1661 | 4.45 | 22 | 46.63 | 207.63 |
| 6 | Miami (Ohio) | 6 | 257 | 1284 | 5.00 | 14 | 42.83 | 214.00 |
| 7 | Ball State | 7 | 298 | 1570 | 5.27 | 13 | 42.57 | 224.29 |
| 8 | Ohio | 9 | 389 | 2029 | 5.22 | 23 | 43.22 | 225.44 |
| 9 | Eastern Michigan | 6 | 279 | 1528 | 5.48 | 15 | 46.50 | 254.67 |
| 10 | Kent State | 7 | 324 | 1890 | 5.83 | 26 | 46.29 | 270.00 |
| 11 | Northern Illinois | 5 | 213 | 1421 | 6.67 | 20 | 42.60 | 284.20 |
| 12 | Akron | 10 | 417 | 2851 | 6.84 | 31 | 41.70 | 285.10 |